REPROGRAMMING · MODULE 03
Reprogramming
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Reprogramming stages
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Original study · SSEA4+ versus CD13+Days 11, 13 and 15 · 6 donors · 36 RNA profiles · donor- and time-adjusted DESeq2 contrast
SELECTED Published R · 531
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Descriptive trajectory · all measured days
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Epigenetic age
DNA methylation · CD13+ / SSEA4+
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CD13+SSEA4+
{{clockControlLabel}}SSEA4 − CD13 · paired difference{{clockControlValue}}
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CD13+SSEA4+
− CD13 higher0 = no mean difference+ SSEA4 higher
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Current context = original published result
Temporal atlas
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Similar temporal profiles
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{{heatNote}} · profile similarity is a separate coefficient.
Context distributions
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Line P10–P90 · box Q1–Q3 · tick median · ● selected
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Shared axis · {{distributionDescription}} · click a day to select it.
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Background: feature density · selected feature stays visible · diagonal: equal expression. Enable points to inspect other features.
Published differential expression
SSEA4+ / CD13+ · days 11–15
{{volcanoNote}} FDR = 0 is drawn at the smallest positive source FDR; exports retain the exact value.
Reprogramming programs
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Drag background to pan · scroll to zoom · links: Jaccard ≥ 0.05, ≥ 3 shared genes
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RNA: GSE165176 · donor-normalized counts, log2(x + 1). miRNA: GSE62776 · source log2 CPM. RNA and DNA methylation describe the same reprogramming experiment, with different assay coverage. The miRNA time course is an independent study. Current-context differences and profile similarities are descriptive; original published coefficients and signatures remain unchanged.